Association of Oral Magnesium with Type-2 Diabetes

26 April, 2011 (22:34) | Diabetes | By: Health news

Seventy-seven percent of participants presented 1 or more magnesium status parameters below the low normal range. Magnesium intake was inadequate in most subjects (82 percent). According to the researchers, “The results presented here show that magnesium intake by the study population was inadequate and that a high percentage of individuals presented alterations in the status of this mineral.”

  • Urine magnesium (2.80 ± 1.51 mmol/d): Low end of normal range=3.00 mmol/L
  • Plasma magnesium (0.71 ± 0.08 mmol/L): Low end of normal range=0.75 mmol/L
  • Erythrocyte magnesium (1.92 ± 0.23 mmol/L): Low end of normal range=1.65 mmol/L

    • Subjects had evidence of poor blood glucose control with fasting glucose of 8.1 ± 3.7 mmol/L or 145 ± 66 mg/dL (reference range: 3.6–5.8 mmol/L or 64.8–104.4 mg/dL); 2-hour postprandial glucose of 11.1 ± 5.1 mmol/L (200 ± 91 mg/dL) (reference range: <10 mmol/L or <180 mg/dl), and HbA1C of 11.4 ± 3.0%. The parameters that influenced fasting glucose were urine, plasma, and dietary magnesium, while plasma magnesium was influenced by creatinine clearance.
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    Magnesium intake by the study population was inadequate and a high percentage of individuals presented alterations in the status of this mineral.

    Practice Implications
    This study set out to assess magnesium intake and magnesium levels in patients with type 2 diabetes. More than 325 magnesium-dependent enzymes allow magnesium to function as a cofactor in a wide range of metabolic reactions. The researchers in this study acknowledge that insulin function is dependent on magnesium, which is responsible for the activation of insulin receptors and for stimulation of proteins and substrates involved in insulin signaling. The researchers cite previous research suggesting that magnesium intake of patients with diabetes is very often below recommended levels. They cite evidence that low levels of magnesium may influence the evolution of the disease by generating further complications.

    The incidence of diabetes in the United States is 7.8 percent for diagnosed and undiagnosed cases. The National Academy of Sciences has determined that most American men only obtain about 80 percent of the recommended daily allowance (RDA) of magnesium, and women average only 70 percent.

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